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Literature summary for 2.8.2.2 extracted from

  • Zhu, J.; Qi, R.; Liu, Y.; Zhao, L.; Han, W.
    Mechanistic insights into the effect of ligands on structural stability and selectivity of sulfotransferase 2A1 (SULT2A1) (2019), ACS Omega, 4, 22021-22034 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.2

Application

Application Comment Organism
synthesis cytosolic sulfotransferases (SULTs) acting as phase II metabolic enzymes can be used in the sulfonation of small molecules by transferring a sulfonate group from the unique co-factor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the substrates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
raloxifene
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + androsterone Homo sapiens
-
 adenosine 3',5'-bisphosphate + androsterone 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens
-
 adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q06520
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + androsterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + androsterone 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + lithocholic acid substrate complex structure analysis Homo sapiens adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + raloxifene substrate complex structure analysis Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
additional information cytosolic sulfotransferases (SULTs) can catalyze the sulfonation of small molecules by transferring a sulfonate group from the unique cofactor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the substrates Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
HST UniProt Homo sapiens
hSULT2A1
-
 Homo sapiens
hydroxysteroid UniProt Homo sapiens
sulfotransferase 2A1
-
 Homo sapiens
SULT2A1
-
 Homo sapiens

General Information

General Information Comment Organism
evolution human cytosolic sulfotransferases (hSULTs) canbe classified into four families (hSULT1, hSULT2, hSULT4, and hSULT6) based on sequence similarity Homo sapiens
additional information mechanism for the effect of cofactor (PAP) and ligands (LCA, raloxifene, alpha-hydroxytamoxifen, ouabain, and 3'-phosphoadenylyl sulfate) on structural stability and selectivity of SULT2A1 from the perspective of the dynamic behavior of SULT2A1 structures. Structural stability and network analyses indicated that the cooperation between PAP and LCA may enhance the thermal stability and compact communication in enzymes. Molecular dynamic simulations, docking study using the crystal structure of the SULT2A1 complex with PAP and lithocholic acid (LCA) (PDB ID 3F3Y). The free SULT2A1 and binary complexes (SULT2A1/LCA and SULT2A1/PAP) are derived from the crystal structure of the SULT2A1 complex with both PAP and LCA (PDB ID3F3Y), modeling, detailed overview. The smaller substrates such as LCA could bind stably to the active pocket in the presence of PAP. The substrates or inhibitors with a large spatial structure need to bind to the open conformation (without PAP) prior to PAPS binding Homo sapiens
physiological function cytosolic sulfotransferases (SULTs) act as phase II metabolic enzymes Homo sapiens